Abstract: According to low communication efficiency, communication out off order and other problems existed in RS- 485 bus transmission technology applied to th e partial monitoring and measuring system in underground mine, M- BUS receiving and transmission circuit of the master computer met with the M- BUS standard and M- BUS receiving and transmission circuit of the master- slave computer based on TSS721 chip were designed independently. A waveform analysis and experiment wer e conducted on the received and transmitted signals. The feasibility, practices, suitability and data transmission relibility of the design were approved. The application 0 n M- BUS receiving and transmission circuits of the master computer and the master- slave computer to the monitoring and measuring system in underground mine, whi ch could complete the communication between the substation and sensor. The design also could be suitable to other related monitoring and measuring systems and Co uld provide idea to study the communication between the up and down levels of the master and slave computers in the other monitoring and measuring systems.