Abstract: Deep coalbed methane(CBM) is the main direction of CBM resource exploration and development in the future. Deep CBM reservoirs are characterized by large burial depths and complex geological structures, so the in-situ stress field is extremely complex, which creates serious challenges to the key technologies of drilling and completion of wells and fracturing of CBM. In order to address the problem of deep CBM in-situ stress modeling, the deep CBM at the eastern margin of the Ordos Basin was taken as the research target. The indoor dynamic and static mechanical parameter experiments and in-situ stress acoustic emission experiments of deep CBM core were carried out systematically. The mechanical and in-situ stress parameters of deep coal rock were obtained, and the conversion model of P-wave and S-wave time difference, dynamic and static mechanical parameters was established. The index model method of deep coal rock structure based on acoustic time difference, density and caliper logging was constructed, and the new model of single well ground stress calculation in deep CBM was developed by coupling the overlying formation pressure, tectonic stress and pore pressure of coal rock. The closure pressure was evaluated by the small fracturing pressure drop curve, and the maximum and minimum tectonic strain inversion was realized by combining the acoustic emission experimental results. The prediction of regional in-situ stress field in deep CBM was carried out by finite element trial calculation method, and the distribution law of in-situ stress in deep CBM was obtained. The results showed that the average horizontal maximum and minimum tectonic strain of the inversion target blocks were 0.29 and 0.11, respectively, and the average maximum and minimum horizontal in-situ stress errors were 9.19% and 9.54%, respectively. Compared with the in-situ stress model without considering the effect of coal structure difference, the established in-situ stress model matched the results of the closure stress calculation better and has better accuracy. It reflected the better applicability and application potential of the in-situ stress model considering the coal structure. It was predicted that the overburden formation pressure > horizontal maximum in-situ stress > horizontal minimum in-situ stress in the in-situ stress field of the target block, showing a normal fault stress state. Vertical fractures were easy to form during fracturing. The horizontal in-situ stress difference was small in most target areas, and the difference between the roof or floor in-situ stress and the coalbed in-situ stress was large. It was conducive to the formation of complex fracture networks and limited the upper and lower layers of fractures, which was suitable for large-scale fracture network stimulation. In-situ stress prediction had important guiding value for sweet spot identification, well placement and fracturing design in key development areas of deep CBM.